LYRICA is known to be substantially excreted by the kidney, and the risk of toxic reactions to LYRICA may be greater in patients with impaired renal function. Because LYRICA is eliminated pregabalin for sale uk primarily by renal excretion, adjust the dose for elderly patients with renal impairment see Dosage and Administration (2.7). The most common dose-related adverse reactions (≥5%) with LYRICA in this study were somnolence, pneumonia, and viral infection see Adverse Reactions (6.1). Multiple oral doses of LYRICA were co-administered with oxycodone, lorazepam, or ethanol. Although no pharmacokinetic interactions were seen, additive effects on cognitive and gross motor functioning were seen when LYRICA was co-administered with these drugs. The following adverse reactions have been identified during postapproval use of LYRICA.
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- There are insufficient data to support a statement regarding the distribution of adverse experience reports by race.
- In comparison, less than 1% of patients in the placebo group withdrew due to each of these events.
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This decrease in pregabalin oral clearance is consistent with age-related decreases in CLcr. Reduction of pregabalin dose may be required in patients who have age-related compromised renal function see Dosage and Administration (2.7). Pregabalin clearance is nearly proportional to creatinine clearance (CLcr). Dosage reduction in patients with renal dysfunction is necessary. Following a 4-hour hemodialysis treatment, plasma pregabalin concentrations are reduced by approximately 50%. For patients on hemodialysis, dosing must be modified see Dosage and Administration (2.7).
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